文章摘要
Peng Zhang,Ziming Wang,Tie Chong,Lihua Zhao.[J].南京医科大学学报,2007,(1):25~28
Analysis of results related to the percent free prostate specific antigen among men without prostate diseases in Xi’an area
投稿时间:2006-03-15  
DOI:10.7655
中文关键词: 
英文关键词: percentage free prostate specific antigen  prostate cancer  Age  relativity  reference range  Xi’an area
基金项目:
作者单位
Peng Zhang Department of Urology the Second Affiliated Hospital of Medical College of Xi’an JiaoTong University Xi’an 710004 China 
Ziming Wang Department of Urology the Second Affiliated Hospital of Medical College of Xi’an JiaoTong University Xi’an 710004 China 
Tie Chong Department of Urology the Second Affiliated Hospital of Medical College of Xi’an JiaoTong University Xi’an 710004 China 
Lihua Zhao Department of clinical laboratorythe Second Affiliated Hospital of Medical College of Xi’an JiaoTong University Xi’an 710004 China 
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中文摘要:
      
英文摘要:
      Objective: To measure the percent of free prostate specific antigen(fPSA) among men without prostate diseases in Xi’an area, and to study the relationship of percent fPSA with age and pathological grade, clinical stage of prostate cancer(PCa) with percent fPSA, and to analyze the difference between the data in China and the overseas data to determine appropriate reference range for Chinese male. Methods: A total of 713 participants were enrolled into the study, with PSA, fPSA in serum measured and the percent fPSA calculated. Out of 713 cases, 679 without prostate diseases were divided into 5 groups by age, and then the relationships of PSA, fPSA and percent fPSA with age were studied, respectively. The relationship of pathological grade and clinical stage with percent fPSA of the 34 participants with PCa was also studied. With the help of the related data of men without prostate disease, the appropriate reference range for Chinese male was established. Results: The increases in PSA or fPSA were correlated with age, while there was no significant correlation between age and percent fPSA. The percent fPSA was also correlated with pathological grade and clinical stage of PCa. The percent fPSA of men without prostate disease in Xi’an area was significantly lower than that in the related overseas data. The reference range of percent fPSA for Chinese male was≥15%. Conclusion: Percent fPSA might be more useful than PSA in the detection of prostate cancer. As the percent fPSA is decreased, the pathological grade is decreased, and the clinical stage is increased, the malignant degree is increased. The reference range of ≥15% is more appropriate for Chinese male.
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