文章摘要
Wei Guo,Chenghong Zheng, Jie Xu.[J].南京医科大学学报,2007,(2):104~107
Effects of poly (ADP-ribose) polymerase inhibitor on early peripheral neuropathy in streptozotocin-diabetic rat
投稿时间:2006-07-20  
DOI:10.7655
中文关键词: 
英文关键词: 3-aminobenzamide  diabetic neuropathy  streptozotocin-diabetic rat
基金项目:
作者单位
Wei Guo Department of Endcrine the First Hospital of Wuhan Wuhan 430030 China 
Chenghong Zheng  
Jie Xu  
摘要点击次数: 1055
全文下载次数: 1165
中文摘要:
      
英文摘要:
      Objective: To explore the effects and mechanisms of poly(ADP-ribose) polymerase(PARP) inhibitor 3-aminobenzamide on nerve lesions in streptozotocin-diabetic rats. Methods: Experimental rats were divided into normal control group(NC group), diabetic control group(DC group)and diabetic group treated with 3-aminobenzamide(DT group).Nerve conduction velocity (NCV),serum superoxide dismutase (SOD) activity and serum malondialdehyde (MDA) concentration,phosphocreatine (Pcr),creatine (Cr) concentration in sciatic nerves were evaluated after 4 weeks. Results: SOD,Pcr activity,and NCV were higher (P < 0.05) and MDA concentration were significantly lower in DT group, compared with DC group (P < 0.01). Meanwhile, ATP and Cr in sciatic nerves were similar in DT group, compared with DC group (P > 0.05). Conclusion: 3-aminobenzamide could alleviate the established functional and metabolic abnormalities of early DPN in the streptozotocin-induced diabetic rat models,which provided a novel approach for prevention and treatment of diabetic neuropathy.
查看全文   查看/发表评论  下载PDF阅读器