文章摘要
Xili Wu,Wanggang Zhang, Wansen Sun,Chenglin Qiao.[J].南京医科大学学报,2007,(5):298~301
Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats
  
DOI:10.7655
中文关键词: 
英文关键词: emodin  glomerular mesangial cell  mesangial cell proliferation  correlative cytokines
基金项目:
作者单位
Xili Wu Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shanxi Province, China 
Wanggang Zhang  
Wansen Sun Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shanxi Province, China 
Chenglin Qiao Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shanxi Province, China 
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中文摘要:
      
英文摘要:
       Objective:To investigate the effects of emodin(EMD) on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods:The effects of EMD on cell proliferation and IL-6 , TGF-βl secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-βl secretion was detected with ELISA. Results:EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-βl secretion of glomerular mesangial, as compared to the model group in rats (P<0.05). Conclusion:EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix(ECM), this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-βl secretion of glomerular mesangial cell in rats.
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