文章摘要
Dan Chen,Anmin Chen,Fengjin Guo.[J].南京医科大学学报,2007,(5):321~323
Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis
  
DOI:10.7655
中文关键词: 
英文关键词: osteoporosis  fracture  osteoprotegerin  osteoclast differentiation factor
基金项目:
作者单位
Dan Chen Department of orthopedics, Shengli Oil-field Central Hospital, Dongying 257034, Shandong province, China  
Anmin Chen Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China 
Fengjin Guo Department of orthopedics, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei province, China 
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中文摘要:
      
英文摘要:
      Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.
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