文章摘要
Changjun Bao,Dr. Dworkin,Daxin Ni,Renjie Jiang,Xian Li, Zhongze Wang,Zhiyang Shi, Liang Li,Hua Wang.[J].南京医科大学学报,2007,(5):324~332
Possible Spread of adenovirus type 3 from poultry to humans: indirect evidence from an outbreak in China
投稿时间:2007-06-07  
DOI:10.7655
中文关键词: 
英文关键词: adenovirus  acute upper respiratory infection  outbreak
基金项目:
作者单位
Changjun Bao Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Province, China 
Dr. Dworkin Illinois Department of Public Health, Chicago 260601, USA 
Daxin Ni National Center for Disease Control and Prevention, Beijing 100050, China 
Renjie Jiang Yan-Cheng Municipal Center for Disease Control and Prevention, Yancheng 224000, Jiangsu Province,China 
Xian Li Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Province, China 
Zhongze Wang Dong-Tai Center for Disease Control and Prevention, Dongtai 224200, Jiangsu Province, China 
Zhiyang Shi Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Province, China 
Liang Li Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Province, China 
Hua Wang Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu Province, China 
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中文摘要:
      
英文摘要:
      Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiologic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIF, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4, 2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respi-ratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.
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