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Research status of the mechanism and treatment for acute pancreatitis complicated with hepatic injury
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This work was supported by technological foundation project of Traditional Chinese Medicine Science of Zhejiang provinice(No.2003C130;No.2004C142),foundation project for medical science and technology of Zhejiang province(No.2003B134),grave foundation project for technological and development of Hangzhou(No.2003123B19),intensive foundation project for technology of Hangzhou(No.2004Z006),foundation project for medical science and technology of Hangzhou(No.2003A004)and foundation project for technology of Hangzhou(No.2005224)

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    Acute pancreatitis(AP) is characterized by its sudden onset and rapid progression and is often complicated by liver injury. AP-induced liver injury may develop into hepatic failure and even result in death. Thus, it is of importance to protect liver function and block injury-related pathways. In the pathogenesis of liver injury in AP, inflammatory cytokines, nuclear factor-kappa B(NF-κB) and oxygen free radicals play important roles. The complexity of the mechanism underlying the development of liver injury exerts, to some extent, a contribution to the difficulties in the treatment of this disease. Currently, the drugs used to treat the disease include L-arginine (L-Arg), calcium ion antagonists, somatostatin and a variety of inflammatory mediator inhibitors. Additionally, some traditional Chinese medicines such as tripterygium, wilfordii, rhubarb and salvia miltiorrhizae may also have some effects. In this article, the pathogenesis of liver injury in AP and its therapy are reviewed.

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Xiping Zhang, Jie Zhang, Ping Yang.[J].南京医科大学学报(自然科学版),2008,28(4):199-204

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  • 收稿日期:2008-05-08
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