文章摘要
Wentao Hui, Ying Zan,Xijng Wang, Huafeng kang,Haitao Guan, Xiaobin Ma.[J].南京医科大学学报,2008,28(4):255~259
Expression of Survivin, p53 and its relationship with apoptosis,proliferation in hepatocellular carcinoma(HCC)
投稿时间:2008-05-11  
DOI:10.7655
中文关键词: 
英文关键词: Survivin  hepatocellular carcinoma  apoptosis  proliferation cell nuclear antigen  p53
基金项目:
作者单位
Wentao Hui Department of Oncology, the Second Hospital Affiliated to Xi’an Jiaotong University, Xi’an 710004,Shaanxi province, China. 
Ying Zan  
Xijng Wang  
Huafeng kang  
Haitao Guan  
Xiaobin Ma  
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中文摘要:
      
英文摘要:
      Objective:To investigate the expression of Survivin p53 and its relationship with apoptosis、proliferation in hepatocellular carcinoma(HCC). Methods:The expression of Survivin, p53 and the proliferation of tumor cells marked by proliferation cell nuclear antigen (PCNA) in 42 cases of HCC were assessed by immunohistochemical method. TUNEL was used to detect apoptosis. Results:Survivin protein was expressed in 30 of 42 cases of HCC(71.4%) and in 4 of 34 cases of adjacent cirrhosis tissues(11.8%). Expression of Survivin protein was negative in 10 cases of normal tissues. Survivin protein positive expression rate in HCC was significantly higher than adjacent cirrhosis tissues and normal tissues(P < 0.001). The increased Survivin protein expression in cancer was significantly associated with histological grade(P = 0.003), p53 protein(P = 0.013), survival time(P < 0.05) and the ratio of proliferative index to apoptotic index(P < 0.01), but was not significantly correlated with age, sex, clinical stage, tumor size, metastasis, AFP, HBs-Ag(P > 0.05).Conclusion:There is a marked increased expression of Survivin in HCC, which may play an important role in breaking the balance of proliferation and apoptosis of HCC cells. The correlation between Survivin and p53 expression in HCC indicates that cooperation between Survivin and p53 plays a certain role in occurrence and /or development of HCC.
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