文章摘要
Yongmei Jin,Pengfei Dou.[J].南京医科大学学报,2008,28(6):391~394
A Study on the Factors influencing insulin resistance in obese adolescents
投稿时间:2008-09-27  
DOI:10.7655
中文关键词: 
英文关键词: Obesity  Insulin resistance  Adolescents
基金项目:
作者单位
Yongmei Jin Departments of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province,China 
Pengfei Dou  
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中文摘要:
      
英文摘要:
      Objective: To explore the factors influencing insulin resistance in obese Chinese children. Methods: We randomly selected 53 children with uncomplicated obesity between 9 to14 years of age, and 29 normal healthy children, matched for age and sex. Anthropometric and plasma biochemical variables(including lipid profiles, glucose and insulin) were measured using standard methods. We calculated insulin resistance(IR) index using homeostasis model assessment(HOMA) methods and measured plasma high-sensitivity C-reactive protein(hs-CRP) levels using nephelometric methods. All statistical analyses were conducted using the statistical package SPSS. Results: Levels of fasting serum insulin, hs-CRP, total cholesterol(TC), low density lipoproteins cholesterol(LDL-C) and IR index were higher in obese children than in controls, while high-density lipoprotein cholesterol(HDL-C) values were lower in the obese children. There was no significant difference in levels of fasting blood glucose between the two groups. HOMA-IR was used as the dependent variable in multivariate regression analysis. Significant independent predictors for insulin resistance adjusted for waist/hip ratio, diastolic pressure (DBP), BMI, triglycerides and HDL-C level were waist circumference(WC), weight and systolic pressure(SBP). Conclusion: Waist circumference, weight and SBP are predictors of insulin resistance syndrome in Chinese adolescents
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