文章摘要
Quanyong Xiang,Minghao Zhou,Ming Wu,Xinya Zhou,Li Lin,Jiuning Huang,Youxing Liang.[J].南京医科大学学报,2009,29(1):33~39
Relationships between daily total fluoride intake and dental fluorosis and dental caries
投稿时间:2008-11-02  
DOI:10.7655
中文关键词: 
英文关键词: Fluoride  Daily total fluoride intake  Dental fluorosis  Dental caries
基金项目:
作者单位
Quanyong Xiang Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China 
Minghao Zhou Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China 
Ming Wu Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China 
Xinya Zhou Suqian Center for Disease Control and Prevention, Suqian 223800, China 
Li Lin Suqian Center for Disease Control and Prevention, Suqian 223800, China 
Jiuning Huang Suqian Center for Disease Control and Prevention, Suqian 223800, China 
Youxing Liang Department of Occupational Health, School of Public Health, Fudan University, Shanghai 200032, China 
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中文摘要:
      
英文摘要:
      Objective: To explore the relationships between the daily total intake of fluoride, dental fluorosis and dental caries. Methods: An epidemiological method was used to investigate the daily total intake of fluoride, dental fluorosis, and dental caries among 236 and 290 children aged 8-13 years in a severe endemic area and in a non-fluorosis control area, respectively. The children were divided into eight subgroups according to each child’s estimated daily total intake of fluoride. The prevalence of dental fluorosis and dental caries in each group was calculated. Results: As expected, elevated levels of fluoride intake were significantly associated with a higher prevalence of dental fluorosis and an increasing amount of more severe defect dental fluorosis. When the daily total F intake was 2.78 mg/child/day, the prevalence of dental fluorosis was nearly 100%, with the prevalence of defect dental fluorosis increasing with increasing fluoride intake. There was also a significant negative (inverse) dose-response relationship between the daily total intake of fluoride and the overall prevalence of dental caries, the prevalence of which decreased when the daily total intake of fluoride increased up to 3.32 mg/child/day. However, at higher levels of daily total intake of fluoride the prevalence of dental caries increased, giving rise to a U-shaped dose-response relationship curve. Conclusion: It is important to monitor total fluoride exposure and protect children from excessive fluoride intake, especially during the years of tooth development.
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