文章摘要
Jing Xiong,Zhonghua Zhu,Jianshe Liu,Yang Wang.[J].南京医科大学学报,2009,29(1):73~77
The effect of root of rhododendron on the activation of NF-kB in a chronic glomerulonephritis rat model
投稿时间:2008-10-12  
DOI:10.7655
中文关键词: 
英文关键词: glomerulonephritis  nuclear factor kappa B  rhododendron  rat model
基金项目:
作者单位
Jing Xiong Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 
Zhonghua Zhu Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 
Jianshe Liu Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 
Yang Wang Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 
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中文摘要:
      
英文摘要:
      Objective: We have explored the role of nuclear factor kappa B (NF-kB) in the pathogenesis of chronic glomerulonephritis, and investigated the effect of rhododendron root on the activation of NF-kB. Methods: Thirty-six Wistar rats were randomly divided into three groups: a control group, a glomerulonephritis model group and a therapy group (glomerulonephritis animals treated with the root of rhododendron). Bovine serum albumin (BSA) nephritis was induced by subcutaneous immunization and daily intraperitoneal administration of BSA. Twenty-four-hour urinary protein and serum creatinine values were measured, and renal pathology was assessed histologically by optical microscopy and electron microscopy. NF-κB activity was determined by an electrophoretic mobility shift assay (EMSA). Results: Compared with the control rats, glomerulonephritis model rats exhibited a significant increase in both 24h urinary protein and serum creatinine, and had abnormal renal histology. The administration of the root of rhododendron ameliorated these changes. NF-κB activity in glomerulonephritis model group was greater than that in rhododendron-treated group, and NF-κB activity was greater in both glomerulonephritis groups than in the control group (P<0.01). Conclusion: These observations suggest that NF-kB plays a role in the pathogenesis of chronic glomerulonephritis, and rhododendron root may attenuate renal damages by downregulating the activation of NF-kB in this model.
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