The differentiation and development mechanism of natural regulatory T cells in the thymus
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摘要:
调节性T细胞（regulatory T cell， Treg）是一群胸腺来源的具有免疫抑制功能的T淋巴细胞，其与自身免疫疾病的发生、外周免疫耐受以及抗感染免疫、肿瘤免疫、移植免疫、变态反应等许多病理性免疫过程有着极其重要的关系。天然型调节性T细胞（natural Treg， nTreg）或称胸腺调节性T细胞（thymus regulatory T cell， tTreg）是调节性T细胞群中很重要的一个亚群。本文将对这一主要亚群及其分化、发育、增殖等过程和相关调控机制进行综述。
Abstract:
Regulatory T cell（Treg） is a thymus-derived T lymphocyte lineage with the ability of immunosuppression in the periphery， and it plays a key role in autoimmune diseases， immune tolerance， immune system， tumor immunity， transplantation immunity， allergic reaction and many other pathological immune processes. Natural Treg cell （nTreg） or called thymus regulatory T cell （tTreg） is a very important T cell lineage in Treg cells. In this paper，we make a review of this T cell lineage on the process of their differentiation，development and proliferation and the regulatory mechanism of them.
