Objective：To analyze the clinical，pathological characteristics and prognosis of 1 102 renal cancer patients in the Urology Department of the First Affiliated Hospital of Nanjing Medical University in the past ten years. Methods：Collected clinical and prognostic follow ⁃ up information of 1 102 patients who were operated at the Department of Urology，the First Affiliated Hospital of Nanjing Medical University from January 2009 to December 2018. Results：The high incidence of kidney cancer was 56 years old (14~91 y)，and the male and female ratios were 66.2% and 33.8%，respectively. The proportion of left and right kidney cancer was 48.1% and 50.5%，and the proportion of bilateral kidney cancer was 1.4%. The average tumor diameter was 4.45 cm(0.2~17.0 cm)， and the proportions of radical nephrectomy and partial nephrectomy were 51.5% and 48.5% ，respectively. The most common pathological type is clear cell carcinoma. The onE-year survival rate after renal cancer surgery and the fivE-year survival rate after surgery were 93.1%. Age over 65 y(HR=1.64)，bilateral tumor(HR=3.71)，radical nephrectomy(HR=3.08)，open surgical approach (HR=2.35)，longer hospitalization time(more than 28 days，HR=3.69)，larger tumor diameter(greater than 7 cm and less than 10 cm， HR=4.68，greater than or equal to 10 cm，HR=6.55)and later clinical stage(stage Ⅱ，Ⅲ and Ⅳ，HR were 4.65，2.65 and 5.80， respectively)，all of which were risk factors affecting the prognosis of patients. Conclusion：Renal clear cell carcinoma is the most common malignant tumor of the kidney，and the overall prognosis after surgical treatment is better. The influencing factors found in this study are useful to guide the clinical precision treatment and improve the prognosis of patients.