Objective：To explore the potential of the circular RNA hsa_circ_0005579 as a new biomarker for the development of pre ⁃eclampsia，and to observe its expression in the placenta of patients with prE-eclampsia and its effect on the proliferation，migration and invasion of trophoblast cells. Methods：The expression of hsa_circ_0005579 was detected in placental tissues obtained from 20 women with pre ⁃ eclampsia and 20 healthy pregnancy controls using real ⁃time quantitative polymerase chain reaction(qRT ⁃ PCR). Clinical information of participants was collected. Ribonuclease R(RNase R)digestion analysis，agarose gel electrophoresis and Sanger sequencing were used to verify hsa_circ_0005579. HTR⁃8/SVneo cells were transfected with hsa_circ_0005179 siRNA，cell counting kit⁃8(CCK⁃8)assay，colony formation assay，EdU test were performed to detect the effect of hsa_circ_0005579 on the proliferation of trophoblast cells. Transwell assay and wound healing assay were used to detect the effect of hsa_circ_0005579 on the migration and invasion of trophoblast cells. Meanwhile，Western blot analysis was used to detect the protein level of migration markers. Results： Hsa_circ_0005579 had a significant high expression in the placenta of PE patients. In addition，compared with the si ⁃NC group，the cell viability was significantly increased，the number of clone formation grew，the cell proliferation rate increased，and the number of migration and invasion did rise，the cell migration rate was upregulated，and the protein levels of migration markers matrix metalloproteinase 2(MMP2)and matrix metalloproteinase 9(MMP9)was enhanced in the si⁃circ_0005579 group. Conclusion：CircularRNA hsa_circ_0005579 is highly expressed in the placenta of patients with pre ⁃ eclampsia，and the proliferation，migration and invasion ability of HTR ⁃ 8/SVneo is enhanced after silencing hsa_circ_0005579. It is expected to provide new targets for early diagnosis and intervention of prE-eclampsia.