Objective：To explore the application value of SonoVue and Sonazoid contrast ⁃enhanced ultrasonography in focal liver lesions. Methods：The clinical and contrast ⁃enhanced ultrasound imaging data of the patients with focal liver lesions in our hospital from January 2020 to December 2021 were analyzed retrospectively. The perfusion pattern，enhancement characteristics of arterial phase，portal phase，delayed phase and late vascular phase(Kupffer phase)of the contrast medium were analysed. Taking the pathological examination results as the“gold standard”，the two examination methods were compared and analyzed. Results：Taking the pathological examination results as the“gold standard”，the accuracy，sensitivity，specificity，positive predictive value and negative predictive value of SonoVue and Sonazoid contrast ⁃enhanced ultrasonography was 88.33%，90.48%，83.33%，92.68%，78.95% and 93.33%，95.24%，88.89%，95.24%，88.89% respectivelv. The kappa value of the consistency test between the two kinds of contrast⁃ enhanced ultrasonography was 0.73. The consistency was at a medium level and the accuracy of SonoVue and Sonazoid contrast ⁃ enhanced ultrasonography in the diagnosis of focal liver lesions was not statistically significant(P=0.373). Conclusion：Sonazoid and SonoVue contrast ⁃ enhanced ultrasonography have no significant difference in the diagnostic accuracy of focal liver lesions，but compared with SonoVue，Sonozoid has a higher quality image，and has the ability to preliminarily judge the differentiation degree of liver tumors，and can also provide a sufficient time for the scanning of other space occupying lesions of the whole liver. Therefore， Sonazoid contrast⁃enhanced ultrasonography has higher clinical application value and broader application prospects.