Acute intestinal ischemic is a common and critical illness，such as superior mesenteric artery embolism. Ischemia reperfusion injury(IRI)is common after treatment. In the pathological process of intestinal IRI，mitophagy is a“doublE-edged sword”. Its role mainly depends on the degree of IRI. In the pathological changes of mild intestinal IRI，it plays a role in alleviating IRI，while in severe cases，it plays the opposite role. The regulation mechanism of mitophagy in intestinal IRI involves multiple signal pathways， such as PINK1/Parkin signal pathway，BNIP3/NIX signal pathway，FUNDC1 signal pathway and Beclin1 signal pathway. With the deepening of related research，the function and mechanism of mitophagy in intestinal IRI is gradually clear，which provides a reference for accurate intestinal IRI.