Progress of lipid components in the pathogenesis of Parkinson’s disease
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R742.5

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    Abstract:

    Parkinson’s disease(PD)is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons(DA) in the substantia nigra pars compacta,accompanied by an accumulation of Lewy bodies and activation of neuroglial cells. Current studies on the correlation between lipid metabolism and PD suggest that different kinds of lipid components play an important role in the progression of PD. However,as it was influenced by a variety of factors(age,gender or etiology)in clinical,it is difficult to obtain a definitive association between lipids and the development of PD. This article aims to review the progress of lipid components in PD, deepen the understanding of the pathology and pathogenesis of PD,and provide new potential targets for the treatment of PD.

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魏越,刘阳,鲁明.脂质成分在帕金森病发生中的研究进展[J].南京医科大学学报(自然科学版英文版),2022,42(9):1341-1348.

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  • Online: September 14,2022
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