Objective：This study aims to observe the changes of coagulation indexes in patients with asymptomatic hyperuricemia， and analyze its correlation with the increasing serum uric acid(SUA)level. Methods：Data were collected from 2 389 patients who have taken physical examinations in the Health Management Center of the First Affiliated Hospital of Nanjing Medical University from January 2018 to September 2021，including 1 497 males and 892 females. Due to the difference in SUA levels between males and females，they were discussed separately. The following coagulation indexes of patients with asymptomatic hyperuricemia were analyzed： prothrombin time(PT)，activated partial thromboplastin time(APTT)，fibrinogen(FIB)，thrombin time(TT)，D-dimer(DD)and platelet (PLT). The data of males and females were separately divided into four groups according to the SUA quartile level. With the increase of the SUA level，the changes of coagulation indexes and its correlation with SUA were analyzed. Results：The prevalence of asymptomatic hyperuricemia was significantly higher in males than that in females(P＜0.001). Both in male and female asymptomatic hyperuricemia patients，data displayed shortened plasma PT(P＜0.05)，while the levels of FIB and PLT increased(P＜0.05). With the increase of SUA level，there were statistically significant differences in PT，FIB and PLT among different groups in males(P＜0.05)， and there existed statistically significant differences in plasma PT among different female groups(P＜0.05). The SUA level of male patients was negatively correlated with PT nor DD，and positively correlated with FIB and PLT(P＜0.05). The SUA level of female patients was negatively correlated with PT，and positively correlated with FIB and TT(P＜0.05). Conclusion：The high SUA levels can increase plasma viscosity，activate platelets and affect exogenous coagulation function，suggesting correct recognition and timely intervention of asymptomatic hyperuricemia in clinical diagnosis and treatment. Periodic physical examination is highly recommended to provide effective guarantee for early prevention of coagulation disorders.