Objective：This study aims to establish and evaluate antibody quantitative detection methods of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)，in order to provide serological data base for corona virus disease-2019(COVID-19)detection and prevention. Methods：The serum and throat swab samples of SARS-CoV-2 infected persons and their close contacts from January to February 2020 were collected，and the SARS-CoV-2 nucleic acid was detected by RT-qPCR，the SARS-CoV-2 specific antibody was detected by microfluidic method and colloidal gold method，respectively，and the consistency of the results was compared and analyzed. Results：The results of detection of SARS - CoV - 2 specific IgG antibody by microfluidic method and colloidal gold method were consistent with those by RT-qPCR，but there were significant differences in IgG positive rates between the early-middle and the late stages by the microfluidic method. Conclusion：As a novel quantitative way to detect SARS-CoV-2 antibodies，the microfluidic method is brief and accurate.