Endometriosis(EMS)has been recognized as a fibrotic disease in recent years，and the fibrosis process of EMS lesions is strongly associated with EMS-related pain，infertility and drug resistance. Myofibroblast(MFB)is the key cell of EMS fibrosis，MFB has a variety of cell sources in eutopic lesions and many activation pathways. Inhibiting MFB activation，promoting apoptosis or cell senescence can inhibit tissue fibrosis. In this paper，the research progress about the correlation between fibrosis and clinical manifestations of EMS，the sources and activation pathways of MFB in EMS，and targeting MFB to inhibit fibrosis are reviewed.