Objective：To compare the fat suppression effect and imaging quality of Dixon and frequency-selective fat-saturation(Fat- Sat)techniques in orbital T2-weighted imaging(T2WI). Methods：Thirty-five healthy subjects were enrolled，with both orbital Dixon- T2WI(Dixon group)and Fat-Sat-T2WI(Fat-Sat group)scans. The fat suppression effect and overall imaging quality for the two groups were scored. The signal intensity of extraocular muscle and ipsilateral temporal muscle，as well as their signal intensity ratio(SIR)were quantitatively measured. Wilcoxon signed rank test were used to compare the subjective scores between groups. Paired -sample t test were used to compare the signal intensity and SIR between groups. Results：Dixon - T2WI had significantly higher scores of fat suppression effect(3.86±0.36 vs. 2.91±0.56，P ＜ 0.001)and overall imaging quality(3.83±0.38 vs. 3.26±0.56，P ＜ 0.001)as compared to Fat - Sat -T2WI. Dixon -T2WI generated both higher signal intensity of extraocular muscle(362.33±107.73 vs. 286.59±78.84，P ＜ 0.001)and ipsilateral temporal muscle(207.26 ± 63.41 vs. 170.19 ± 51.93，P ＜ 0.001)than Fat - Sat - T2WI. However，there was no significant difference in their SIR between the two groups(1.83±0.54 vs. 1.77±0.49，P=0.239). Conclusion：Dixon-T2WI outperforms Fat-Sat-T2WI in both fat suppression effect and overall imaging quality，without significantly altered SIR. This technique can provide a more reliable diagnosis basis for clinic.