Objective：To evaluate the impact of transjugular intrahepatic portosystemic shunt(TIPS)on splenic volume and blood corpuscle. Methods：The general information，laboratory and CT imaging data of 120 patients with portal hypertension due to cirrhosis were retrospectively collected before and 1，3，6 and 12 months after TIPS from May 2015 to December 2020 in Department of Interventional Radiology，the First Affiliated Hospital of Nanjing Medical University. The changes of splenic volume，platelet count，hemoglobin，and leukocyte count before and after TIPS were evaluated by Friedman test and Spearman correlation analysis. Results：Changes of observed indexes of 120 patients from preoperation to postoperative 12 months：the splenic volume decreased from 749.3(479.0，1152.2)cm³ to 577.4(343.0，884.1)cm³ (P ＜ 0.001)，platelet(PLT)count increased from 50(40，80)×10⁹ /L to 86.5(60，124)×109 /L(P ＜ 0.001)，hemoglobin(Hb)increased from 81(70，94)g/L to 121(106，132)g/L(P ＜ 0.001)and the leukocyte (WBC)count increased from 4.1(2.5，6.6)×109 /L to 5.9(5.0，7.0)×10⁹ /L(P ＜ 0.001). The rate of change in splenic volume and corpuscle was the most obvious in the first month after TIPS and the spleen had shunk by 6.5%，and the PLT count，Hb，and WBC count increased by 15.1%，17.3% and 11.2% respectively. In addition，the rate of increase in PLT was significantly correlated with the rate of decrease in splenic volume. Conclusion：The splenic volume is decreased and PLT count，Hb and WBC count are increased after TIPS，and the improvement is the most obvious in the first month after TIPS. The rate of increase in PLT is significantly related to the rate of decrease in splenic vloume.