COVID-19，caused by the severe acute respiratory syndrome coronavirus 2(SARS-COV-2)in 2019，resulted in a global pandemic and had impacts on human lives，public healthcare system，and the global economy. Vaccination is the most important intervention to protect the population from coronavirus disease 2019(COVID-19). The period before and during pregnancy and during lactation is of widespread interest and attention，to study the impact of COVID-19 vaccination on them and their offspring is of great significance. In this review，we aimed to collect relevant reports so far on the impact of COVID - 19 vaccination on male and female reproductive system as well as the effects during pregnancy and lactation，and summarize the clinical data about the safety of COVID- 19 vaccine on males and females before and during pregnancy and during lactation，and on their offspring，in the hope of providing useful information for future systematic evaluation the safety and use of COVID-19 vaccine in this population