Objective：This study aims to explore the effect of overexpressing or silencing long intergenic non - protein coding RNA 01518(LINC01518)on the cell proliferation induced by IL -17 in non - small cell lung cancer(NSCLC). Methods：The IL -17 receptor A(IL-17RA)expression in NSCLC cell lines(PC9，H1299 and H1975)was first examined using Western blot. Then H1299 and PC9 cells were exposed to IL-17 for different time，and the cell proliferation was detected by CCK-8 assay. Based on the results of up-regulated lncRNAs detected by lncRNA microarray in IL-17-stimulated H1299 and PC9 cells，several lncRNAs were selected and verified by RT - PCR and Real - time PCR. Additionally，the constructed plasmids of pcDNA3.1/LINC01518 or shLINC01518 were transfected into H1299 cells，and H1299 cell proliferation were examined by CCK-8，EdU and colony formation assays. Results： IL-17RA could express in 3 kinds of NSCLC cell lines. The cell proliferation and LINC01518 were obviously up-regulated in H1299 and PC9 cells treated by IL-17. Besides，LINC01518 overexpression could markedly promote the cell proliferation，while LINC01518 gene knockdown followed by IL - 17 treatment did not enhance cell proliferation. Conclusion：LINC01518 can promote H1299 cell proliferation induced by IL-17 stimulation.