Objective：Peripheral T -cell lymphomas(PTCL)is a heterogeneous group of non -Hodgkin’s lymphomas. The current study aims to analyze the clinical features of PTCL patients，and explore new factors that affected the progression-free survival(PFS) and overall survival(OS)，with which to establish new prognostic models. Methods：The clinical data of 202 patients with PTCL from the First Affiliated Hospital of Nanjing Medical University between July 2009 and September 2021 were retrospectively analyzed. Kaplan - Meier method，univariate and multivariate Cox regression analysis were performed for the survival analysis and prognostic factor evaluation. Results：The median PFS and OS of all PTCL patients were 11 months and 43 months respectively. Patients with lower level of hemoglobin(Hb)showed shorter PFS(9 months vs. 44 months，P ＜ 0.001)and OS(24 months vs. 83 months，P=0.002) than patients with normal level of Hb. The ECOG scores ＞1(P=0.009)and lower Hb level(P=0.007)were independent risk factors for PFS. Age ＞60 years(P=0.015)and the ECOG score ＞1(P=0.002)were independent risk factors for OS. International prognostic index (IPI)or prognostic index for T-cell lymphoma(PIT)combined with the Hb level improved the accuracy of predicting PFS of patients with PTCL. Conclusion：The level of Hb may be a good candidate for predicting prognosis of patients with PTCL. The Hb level combined with IPI and PIT can improve the ability to predict prognosis of patients with PTCL.