Objective：To evaluate the diagnostic ability of dynamic-contrast enhanced magnetic resonance imaging(DCE-MRI)and apparent diffusion coefficient(ADC)in differentiating smooth muscle tumours of uncertain malignant potential(STUMP)or malignant uterine mesenchymal tumours from leiomyomas that manifests restricted diffusion on diffusion-weighted imaging(DWI). Methods：A total of 68 patients with pathologically confirmed uterine mesenchymal tumors that manifest restricted diffusion on DWI(b=800 s/mm2 ) were included between January 2016 and September 2021. We assessed conventional MR features of the lesions. Histogram analysis was performed based on ADC and DCE -MRI，and the derived quantitative parameters were compared between STUMP or malignant uterine mesenchymal tumours(n=23)and leiomyomas that manifest restricted diffusion on DWI(n=45). Receiver operating characteristic(ROC)curve was used for evaluating diagnostic performance. Results：The incidence of cystic necrosis in the STUMP or malignant group was higher than that in the non -malignant group(34.8% vs. 8.9%，P=0.016). ADC_median and V_{e median} of the STUMP or malignant group were significantly lower than nonmalignant group(P ＜ 0.001，P=0.012)，with the highest area under the curve(AUC) for distinguishing STUMP or malignant uterine mesenchymal tumours reaching 0.795 and 0.713. ADC_median+ V_{e median} improved AUC to 0.850. ADC_median+V_{e median}+with or without cystic necrosis yield the highest AUC(0.883). Conclusion：The combination of ADC，DCE-MRI parameters and conventional MR features may serve as sensitive indicators for differentiating malignant uterine mesenchymal tumours from leiomyomas showing restricted diffusion on DWI.