Objective：The current study aims to investigate the prognostic role of nutritional status，including controlling nutritional status(CONUT)score and prognostic nutritional index(PNI)，in patients with diffuse large B cell lymphoma(DLBCL). Methods：The clinical data of 105 patients with DLBCL at the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University were retrospectively collected. And the patients’CONUT score and PNI were calculated. The cut-off values of CONUT score and PNI were determined by ROC curves，and were 6.5 and 47.28 respectively. The patients were grouped according to the cut-off values. Kaplan- Meier survival analysis，univariate and multivariate COX regression analysis and Spearman correlation analysis were performed sequentially. Results：Survival curves demonstrated that CONUT score and PNI had a predictive effect on OS of patients(P ＜ 0.05). Univariate analysis showed that CONUT score，PNI，IPI risk score，albumin and cholesterol were prognostic factors for OS of patients. The results of multivariate analysis showed that CONUT score had an independent prognostic effect on OS in DLBCL patients(HR= 2.742，95%CI：1.030~7.300，P ＜ 0.05)，and PNI was not an independent prognostic factor for OS of patients(HR=0.526，95%CI： 0.135~2.047，P=0.35). Correlation analysis showed a high negative correlation between the two nutritional status indicators(r=-0.79， P ＜ 0.01). Conclusion：The CONUT score is an independent prognostic factor for DLBCL patients，and the higher the CONUT score of patients，the worse the prognosis.