Objective：To explore the experience of liver re-transplantation for chronic graft failure. Methods：A retrospective analysis was conducted on 4 patients who underwent re-transplantation for chronic graft dysfunction in our team from January 2019 to December 2020，focusing on surgical time，intraoperative blood transfusion volume，ICU stay，total hospital stay，postoperative complications，and a literature review was conducted to summarize the experience of re-transplantation. Results：The surgery of all four patients were successful，using the in situ classic liver transplantation procedure，with an average operation time of 420 min（385-480 min），an average intraoperative infusion of 11.5 U of red blood cells（8-16 U），and an average of 1 350 mL of fresh frozen plasma （1 000-2 075 mL）. The average ICU stay after surgery was 3 days（2-4 days），and an average postoperative hospitalization of hospital stay after surgery was 21 days（14-31 days）. Among the 4 patients，3 had no significant complications during hospitalization. 1 patient developed stenosis of the inferior vena cava and was cured after percutaneous balloon dilation. Regular follow-up after discharge has shown stable conditions in 3 cases，while 1 patient died 20 months after surgery due to non-ischemic biliary disease. Conclusion：Liver re-transplantation is the only effective treatment for chronic graft failure after liver transplantation. By selecting suitable cases， improving surgical techniques，and enhancing perioperative management，better therapeutic effects are expected to be achieved.