Thyroid hormone metabolites，as important regulators of physiology and pathology，have received more and more attention. In addition to having similar effects to thyroid hormones in modulating hyperglycemia，improving dyslipidemia and promoting brain development，researchers have also found that they play an important role in protecting the heart from myocardial ischemia reperfusion injury and inhibiting the proliferation of tumor cells. Further investigations of thyroid hormone metabolites are needed to fully reveal their physiological actions and mechanisms，and this may open new perspectives for the treatment of metabolic diseases， neurological diseases and cancer.