Objective：To investigate the structure，antioxidant，antimicrobial and biocompatibility of rosmarinic acid（RA）and zinc （Zn）complexes. Methods：The structures of zinc complexes with rosmarinic acid（RA-Zn）were analyzed by scanning electron microscopy，infrared and ultraviolet-visible spectroscopy. The effects of RA and RA-Zn on the proliferative activity of osteoblasts were compared by cell proliferation assay. The antioxidant properties were analyzed by ferric ion reducing antioxidant power assay and 2，2- azinobis（3-ethylbenzothiazoline-6-sulfonic acid）ammonium salt（ABTS）free radical scavenging assay. The inhibitory activities of RA and RA -Zn against Straphylococcus aureus were compared by the minimum inhibitory concentration assay. Results：The complex （RA -Zn）was successfully synthesized. On the 5th day of treatment，the effect of RA-Zn on promoting osteoblast proliferation was superior to that of RA（P < 0.05）. RA-Zn of 200 μmol/L had stronger antioxidant capacity than RA（P < 0.05）. RA inhibited Staphylococcus aureus activity at the concentration of ≥400 μmol/L（P < 0.05），while RA-Zn showed these inhibitory effect at the concentration of ≥ 25 μmol/L（P < 0.05）. Conclusion：The antioxidant and antimicrobial properties are enhanced by the complexation of RA and Zn ions，which promotes osteoclast proliferation.