Lipoxin A₄（LXA₄）is a natural pro -catabolic molecule produced by endogenous fatty acids that is known as the“brake signal”of inflammatory factors. It has a powerful anti-inflammatory effect，but its metabolism is fast，and LXA₄ analogues are relatively more stable and also have certain anti-inflammatory effects. The star cell in the fight against inflammation，the macrophage，is a vital component of our natural immunological barrier and plays a crucial role in inflammation reduction，as does LXA₄. LXA₄ and its analogs are intricately related to macrophages in the anti-inflammatory process. The interactions between the two in the inflammatory response are examined in order to generate novel ideas for treating a variety of inflammation-related disorders.