Objective：To explore whether atorvastatin（Ator）can induce ferroptosis in pancreatic β- cell line MIN6 cells and its possible mechanism. Methods：MIN6 cells were divided into control group，Ator group，Ator+apoptosis inhibitor（Z-VAD-FMK）group， Ator+necrostatin-1（Nec-1）group and Ator+ferrostatin-1（Fer-1）group. Cell viability was detected by cell counting kit-8（CCK-8） method. The ultrastructure of cells was observed by transmission electron microscopy. The levels of reactive oxygen species（ROS）and Fe²⁺ were observed by fluorescence microscopy. The contents of malondialdehyde（MDA）and glutathione（GSH）were detected by enzyme-linked immunosorbent assay（ELISA）method. Real-time quantitative PCR was used to detect the mRNA levels of caspase-3， receptor-interacting protein kinase 3（Ripk3），acyl-CoA synthetase long-chain family member 4（Acsl4），prostaglandin endoperoxidase synthase 2（Ptgs2）and glutathione peroxidase 4（Gpx4）. Western blot was used to detect the proteins levels of 4-hydroxynonenal （4-HNE）and GPX4. Results：Compared with the Ator group，cell viability of MIN6 was higher in Ator+Z-VAD-FMK group and Ator+ Fer -1 group（P ＜ 0.01）. MIN6 cells，which were treated with Ator，exhibited the characteristic morphologic features associated with apoptosis，ferroptosis and autophagy under transmission electron microscopy. Compared with the control group，the levels of the intracellular Fe²⁺ ，MDA and ROS in the Ator group were increased and GSH was decreased. The mRNA relative expression levels of caspase-3，Acsl4 and Ptgs2 were increased，as well as the protein relative expression level of 4-HNE（all P ＜ 0.05）. The mRNA and protein relative expression levels of GPX4 were decreased（P ＜ 0.05）. Compared with the Ator group，the levels of the intracellular Fe²⁺ ，MDA and ROS in the Ator+Fer-1 group were decreased and GSH was increased. The mRNA relative expression level of Acsl4 was decreased and Gpx4 was increased（all P ＜ 0.05）. The protein relative expression levels of 4-HNE was decreased and GPX4 was increased，though the changes were not statistically significant. Conclusion：Atorvastatin may induce ferroptosis in MIN6 cells by down-regulating GPX4 expression through inhibiting mevalonate pathway.