Objective：To investigate the effects of tracheal tube cuff pressure control on intraoperative hemodynamics and postoperative sore throat during laparoscopic colorectal surgery. Methods：Ninety -four patients who underwent laparoscopic radical surgery for colorectal cancer were selected. Patients were randomly divided into Group H（tracheal tube cuff pressure control group，n= 48）and Group L（finger sensation method group，n=46）. The pressure of the tracheal tube cuff in Group H was controlled at 25-30 cmH₂O，while patients in Group L were only be monitored for cuff pressure. Heart rate（HR），mean arterial pressure（MAP），cuff pressure，and airway pressure were continuously monitored and recorded at seven time points including pre -induction of anesthesia （T0），after intubation（T1），before establishment of pneumoperitoneum（T2），after establishment of pneumoperitoneum（T3），after Trendelenburg position（T4），before tracheal extubation（T5），and after tracheal extubation（T6）. Additionally，the incidence and severity of sore throat and hoarseness were investigated in patients at 2 h，12 h and 24 h after surgery. Results：The HR，MAP，and cuff pressure in Group L were significantly higher than that in Group H at time points T1- T5（P ＜ 0.05）. The airway pressure in both groups significantly increased at T3（P ＜ 0.05）and further increased at T4（P ＜ 0.05），but without significant difference between the two groups. The incidence of postoperative sore throat at 2 h and 12 h was lower in group H than that in group L（P ＜ 0.05）. There was no statistical difference in the incidence and severity of postoperative hoarseness between the two groups（P ＞ 0.05）. Conclusion：In patients undergoing laparoscopic colorectal surgery，tracheal tube cuff pressure control can reduce the incidence of postoperative sore throat and maintain the relative stability of intraoperative hemodynamics.