Epilepsy is a kind of brain dysfunction caused by abnormal synchronous discharge of brain neurons，and is one of the common diseases of the nervous system. Patients need to take anti-epileptic drugs regularly for a long time to achieve seizures-free. For pregnant women，antiepileptic drugs can enter the fetus through the placental barrier causing adverse effects. Lamotrigine and levetiracetam have the lowest potential teratogenic risk，oxcarbazepine has a low risk，topiramate has high risk，while valproic acid has the most severe teratogenic effect and negative effects on the neuropsychological development of children exposed in utero，and should be avoided as far as possible. At present，the management of antiepileptic drugs is still a difficult clinical problem. Pre-pregnancy preparation and rational decision-making of antiepileptic drugs usage during pregnancy are very important.