Objective：As the most common metabolic disease，diabetes is closely related to cardiovascular disease and is an independent risk factor for the occurrence of acute myocardial infarction. Nuclear factor erythroid-2-related factor 2（NRF2）is a key regulator of the cellular antioxidant response，which increases the transcription of downstream antioxidant genes by interacting with other proteins and binding to antioxidant response elements，thereby maintaining the dynamic balance of redox states. Some studies have shown that NRF2 is involved in the regulation of the occurrence and development of diabetic myocardial ischemia - reperfusion injury，but its mechanism is not yet fully understood. This paper mainly reviews the research progress of NRF2 signaling pathway related to diabetic myocardial ischemia - reperfusion injury and NRF2 targeted therapies，providing new insights for the clinical treatment of diabetic myocardial ischemia-reperfusion injury.