Objective：To prepare a soothing liposome emulsion using madecassoside（MC）and ectoin（EC）as the primary ingredients and to evaluate its transdermal absorption. Methods：The optimal ratio of MC and EC that produced anti-inflammatory and barrier repair activities was determined through cellular assays；MC -EC liposomes were prepared using the thin film hydration. The particle size，dispersibility coefficient，and Zeta potential were measured using a Malvern particle size analyzer. The morphology was observed under transmission electron microscope. The contents of MC and EC in the solution were determined by high - performance liquid chromatography. The encapsulation rate and drug loading capacity were determined by the dialysis method. The transdermal characteristics of the liposome emulsion were evaluated via the Franz diffusion cell method. Results：The cell experiments determined that the best anti-inflammatory and barrier-repairing activities were achieved with a MC to EC mass ratio of 1∶9. Under these parameters， the liposome preparation conditions were optimized with a phosphorus - bile ratio of 5∶1 and a drug - to - lipid ratio of 1∶10. The encapsulation rate of MC in the liposomes was 51.33%，and the drug loading capacity of MC was 0.35%，the encapsulation rate of EC was 26.39%，and the drug loading capacity of EC was 1.20%. The liposomes had a particle size of 166.53 nm，the Zeta potential of-29.63 mV，and the PDI of 0.20. Over a 24 h period，the solution demonstrated a lower cumulative permeability compared with the aqueous control，without exhibiting an abrupt release；instead，a sustained release effect was observed. Conclusion：The MC and EC liposome emulsion prepared in this experiment has a high drug load and stable internal particle distribution，and may achieve slow - release effect on the skin surface and prolong the action time of the effective substance.