Objective：The aim of this study was using multimodality echocardiographic parameters to evaluate early changes in systolic and diastolic functions of left ventricle in patients with hypertrophic cardiomyopathy（HCM）. Methods：A total of 54 HCM patients were selected，including 34 with non - obstructive HCM patients and 20 with obstructive HCM patients，who visited the outpatient department of the First Affiliated Hospital of Nanjing Medical University from October 2019 to June 2021. Additionally，30 healthy individuals were chosen as a control group. Multimodality echocardiographic parameters were used to compare the changes in left ventricular systolic and diastolic functions among three groups. Results：HCM patients exhibited reduced left ventricular systolic and diastolic function. Obstructive HCM patients showed more significant reduction in global longitudinal strain（GLS），global work index（GWI），global constructive work（GCW），and global work efficiency（GWE）. The difference in global waste work（GWW）among the three groups was not statistically significant. Conclusion：Multimodality echocardiographic parameters can comprehensively evaluate the early impairment of left ventricular systolic and diastolic functions in HCM patients，providing important basis for clinical diagnosis，treatment，and prognosis as early as possible.