Objective：To investigate the correlation between a history of stroke and the clinical manifestations in patients with coronary heart disease（CHD）. Methods：A total of 2 327 CHD patients hospitalized at the First Affiliated Hospital of Nanjing Medical University and Wuxi Second People’s Hospital from September 2018 to September 2021 were enrolled. The clinical manifestations and general information of the patients were collected. Patients were divided into two groups based on their history of stroke：the stroke group and the non-stroke group. Additionally，patients were stratified according to the New York Heart Association（NYHA）functional classification into groups with less than grade Ⅲ and grade Ⅲ or above. Multivariable logistic regression analysis was used to assess the relationship between a history of stroke and the clinical manifestations of CHD patients. Results：Among the 2 327 CHD patients， 280 had a history of stroke，while 2 047 did not. Significant differences were observed between the two groups in terms of total cholesterol （TC），triglyceride（TG），high-density lipoprotein cholesterol（HDL-C），diabetes，hypertension and a history of renal insufficiency（all P ＜ 0.05）. After adjusting for important covariates such as age，gender，and body mass index（BMI），multivariable logistic regression analysis revealed that a history of stroke was independently and positively associated with the NYHA functional classification of CHD patients （OR=1.85，95%CI：1.14-3.01，P=0.013）. The correlation between stroke history and NYHA functional classification in coronary heart disease patients was further confirmed in subgroup analysis. Conclusion：A history of stroke is closely associated with functional classification of CHD patients，and may potentially serve as an indicator for the functional status of patients with CHD.