Objective：To investigate the clinical significance of anti-SSA positive with or without anti-SSB positive in children with lupus nephritis. Methods：The clinicopathological data of children with lupus nephritis newly diagnosed in the Nephrology Department of Nanjing Children’s Hospital from January 1，2018 to January 1，2023 were retrospectively analyzed. Eighty-five children with lupus nephritis were enrolled in this study，including 34 children in the anti-SSA positive with or without anti-SSB positive group（Group A） and 51 children in the anti-SSA and anti-SSB negative group（Group B）. Group A was divided into Group A1（anti-SSA positive，22 children）and Group A2（anti - SSA and anti - SSB positive，12 children）. The clinical manifestations，SLEDAI - 2K scores and pathological features were compared among all groups，and the remission of lupus nephritis after six months of treatment was followed up. Results：The Group A and Group A1 had no statistical significance compared with the Group B，respectively（P ＞ 0.05）. The incidence of rash in the Group A2 was lower than that in the Group B，the difference was statistically significant（P ＜ 0.05），and the non - remission rate in the Group A2 was higher than that in the Group B，the difference was statistically significant（P ＜ 0.05）. Conclusion：Children with anti-SSB positive lupus nephritis are all accompanied by anti-SSA positive，and children with both anti-SSA and anti -SSB positive lupus nephritis have a lower incidence of rash clinically，but a higher renal unremission rate for half a year， which may require more aggressive renal treatment.