Exploring the risk of pulmonary arterial hypertension in patients with connective tissue disease based on nailfold video capillaroscopy
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1Department of Rheumatology,2Department of Cardiology,the First Affiliated Hospital with Nanjing MedicalUniversity,Nanjing 210029 ,China

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R544.1;R593.2

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    Abstract:

    Objective:This study aims to evaluate the predictive value of nailfold capillaroscopy(NVC)in the diagnosis of patients with connective tissue disease(CTD)associated pulmonary arterial hypertension(PAH). Methods:A retrospective analysis was conducted on 147 patients with connective tissue disease(CTD)who were hospitalised in the Department of Rheumatology and Immunology of the First Affiliated Hospital with Nanjing Medical University and underwent NVC from September 2022 to June 2024. According to whether they were combined with pulmonary arterial hypertension(PAH)or not,CTD patients were divided into two groups:CTD - PAH and CTD - nonPAH. Risk factors for PAH in CTD patients were screened by multifactorial logistic regression analysis. A nomogram prediction model was constructed based on this multifactorial logistic regression analysis and the model performance was evaluated using the receiver operating characteristic(ROC)curve. Results:Among the CTD patients,52(35.4%) were included in the CTD-PAH group. The capillary length was longer in the CTD-PAH group than in the CTD-nonPAH group[262.0 (207.0,308.0)vs. 202.0(160.0,272.0),P < 0.05],and the pericapillary score was higher than that in the CTD-nonPAH group[2.40 (0.80,3.92)vs. 1.90(0.40,2.80),P < 0.05]. Logistic regression analysis showed that both long capillary length and high pericapillary score increased the risk of PAH occurrence[OR=1.300(95% CI:1.100-1.500),OR=1.268(95%CI:1.025-1.568)]. The area under the ROC curve of the nomogram prediction model amounted to 0.705(95% CI:0.618-0.792,P < 0.05). Conclusion:The findings suggest that nailfold capillary characteristics,including capillary length and pericapillary score,may serve as independent predictors of PAH in patients with CTD. These results provide a new basis for early screening and individualized therapeutic strategies in CTD-PAH patients.

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ZHOU Zhangdi, ZHANG Yixin, DAI Jiayi, LI Dongyu, SUN Xiaoxuan, WANG Qiang. Exploring the risk of pulmonary arterial hypertension in patients with connective tissue disease based on nailfold video capillaroscopy[J].,2025,45(9):1276-1285.

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  • Received:November 20,2024
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  • Online: September 11,2025
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