Neutrophil extracellular trap（NET），a reticular structure composed of DNA fibers，histones，and antibacterial proteins released by neutrophils，can trap and eliminate foreign pathogens and play a significant role in the initiation and development of tumors. The formation and release of NET are regulated by various factors from the tumor microenvironment，including signaling molecules released by tumor cells，inflammatory cytokines，oxidative stress，and angiogenesis. In addition，NET interacts with immune cells in the tumor microenvironment，collectively shaping the immune characteristics of the tumor microenvironment and participating in critical biological processes，such as metabolic regulation of tumor cells，tumor metastasis，tumor - related thrombosis，and tumor angiogenesis，all of which impact tumor progression and patient prognosis. This review focuses on the multiple mechanisms of NET in tumor progression，explores the mechanisms of NET in regulating tumor cell proliferation and metastasis，altering tumor microenvironment，and affecting tumor angiogenesis and immune escape，as well as the potential application prospect of NET as biomarkers for clinical diagnosis and prognosis，to reveal the significant role of NET in tumor biology and provide a theoretical foundation for future research and clinical application