Depressive disorders have become one of the most common and significantly harmful psychological conditions among adolescents. The incidence of nonsuicidal self -injury（NSSI）in adolescents with depressive disorders is on the rise，posing a severe challenge to their physical and mental health. Previous studies have indicated that the mechanisms underlying adolescent depressive disorders and NSSI are complex，involving the interplay of multiple factors，including neurotransmitter levels，hormonal changes， immune -inflammatory responses，genetic susceptibility，and psychosocial influences. NSSI is not only an important manifestation of risky behavior in patients with depressive disorders but also closely related to suicide risk. Current treatments for adolescent depressive disorders and NSSI are primarily centered on psychotherapy，with multimodal interventions，including pharmacotherapy and physical treatments，as adjuncts. Different intervention approaches have shown certain differences in improving NSSI behaviors and prognosis. This article reviews the relevant epidemiology，pathophysiological mechanisms，and risk factors，and systematically summarizes the major research advances and clinical intervention strategies for adolescent depressive disorders with NSSI in recent years，aiming to provide theoretical references for further optimizing treatment models and improving patients’prognosis and quality of life.