Objective：To analyze and compare the trends in the incidence of four types of hepatitis between Jiangsu province and the whole nation，reveal the regional characteristics and current status of hepatitis incidence in Jiangsu province，and provide a reference for hepatitis prevention and control efforts in Jiangsu province and the whole nation. Methods：Descriptive epidemiological methods，average annual percent change and spatiotemporal scan statistical methods were used to analyze and compare the incidence data of four types of hepatitis（hepatitis A，B，C and E）in Jiangsu province and the whole nation from 2004 to 2022. Results：The average incidence rates（1/100 000）of four types of hepatitis in Jiangsu province and nationwide from 2004 to 2022 were 1.55 and 2.72for hepatitis A，18.70 and 75.24 for hepatitis B，3.50 and 11.85 for hepatitis C，and 3.80 and 1.77 for hepatitis E，respectively. The change trend of incidence rate in recent years is as follows：nationwide，hepatitis A remained a stable trend（2012-2022，P>0.10），hepatitis B remained a stable trend（2014-2022，P>0.50），hepatitis C displayed a downward trend（2019-2022，P<0.001），andhepatitis E remained a stable trend（2013-2022，P>0.50）；In Jiangsu province，hepatitis A remained a stable trend（2013-2022，P>0.20），hepatitis B showed an upward trend（2012-2022，P<0.05），hepatitis C showed an upward trend（2004-2022，P<0.001），and hepatitis E demonstrated a declining trend（2011-2022，P<0.001）. Spatiotemporal scan statistical analysis revealed that three low-incidence clusters for hepatitis A nationwide all included Jiangsu province，one of three low - incidence clusters for hepatitis B nationwide included Jiangsu province，two of four low-incidence clusters for hepatitis C in nationwide included Jiangsu province，and three high-incidence clusters for hepatitis E in nationwide all included Jiangsu province. Conclusion：From 2004 to 2022，nationwide，hepatitis B had the highest average incidence rate，followed by hepatitis C，hepatitis A，and hepatitis E，respectively. In Jiangsu province，hepatitis B also had the highest average incidence rate，followed by hepatitis E，hepatitis C，and hepatitis A respectively. The average incidence rates of hepatitis A，B，and C in Jiangsu province were lower than the national average，while the average incidence rate of hepatitis E was higher than the national average. The focus of the national hepatitis prevention and control strategy should be on reducing the incidence rate of hepatitis B and shifting the stable trends of hepatitis A（2012- 2022）and hepatitis E（2013- 2022）incidence rates to a declining trend. The focus of hepatitis prevention and control strategy in Jiangsu province should be on reducing the incidence rates of hepatitis B and hepatitis E，as well as reversing the upward trend of hepatitis C（2004-2022）incidence and the stable trend of hepatitis A（2013-2022）incidence to a declining trend.