Lysine-specific demethylase 6B（KDM6B）is an important epigenetic factor in the Jumonji C domain-containing protein family（JmjC）. It not only plays an epigenetic role in cell differentiation，inflammatory response，tissue homeostasis，and neurological diseases，but also plays an important role in macrophage function and immune response. KDM6B is the sole member of the JmjC family that can respond to Toll-like receptor（TLR）signals. It is activated under the stimulation of TLR signals and thereby fulfills its function. Studies have found that KDM6B can affect macrophages by regulating the polarization of macrophages，affecting the expression of cytokines and participating in the regulation of tumor microenvironment. Therefore，KDM6B plays an important role in the physiological and pathological processes such as immune response，inflammatory response，and tumor. As a key epigenetic factor，KDM6B regulates the functions of macrophages，including the polarization，inflammatory response，and pro-fibrotic activities of macrophages，and is expected to become a potential target for the study of immune，inflammatory，and tumor-related diseases.