Post - stroke cognitive impairment（PSCI），as a common and highly disabling complication following stroke，not only severely impairs patients’quality of life but also significantly increases the risk of stroke recurrence and mortality. In the exploration of its pathogenesis，amino acid metabolic disorder has gradually been recognized as one of the key pathophysiological factors. Against this backdrop，this paper systematically reviews the research progress on major amino acid metabolic disorders in the core pathogenesis of PSCI in recent years，covering their underlying mechanisms，potential as biomarkers，and relevant interventional strategies，while highlighting their critical roles in neuroinflammation，oxidative stress，neurotransmitter imbalance，and other related aspects. These studies help deepen the understanding of the pathological mechanisms of PSCI，and also provide new insights and tools for early diagnosis，precise treatment，and prognostic evaluation of the disease，thus holding important clinical significance and potential application value.