Population aging is a major global challenge today，in which inflammaging，as one of the core features of aging，is closely associated with the development of various age-related diseases. Myeloid-biased differentiation of hematopoietic stem cell（HSC）is a key manifestation of immunosenescence，characterized by enhanced differentiation of HSC into myeloid cells and reduced lymphoid differentiation，leading to immune dysfunction and driving chronic inflammation. This review systematically elucidates the interaction mechanisms between HSC myeloid-biased differentiation and inflammaging，including bone marrow microenvironment inflammation， epigenetic alterations，and mitochondrial dysfunction. Furthermore，it summarizes targeted intervention strategies，such as blocking the interleukin - 1 signaling pathway，modulating epigenetic modifications，remodeling the bone marrow microenvironment，and clearing senescent cells，which have shown potential in animal models to reverse myeloid-biased differentiation and improve immune function.