The oculomotor mechanism of joint attention in children with autism spectrum disorder based on multimodal neuromodulation music therapy
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1Office of Medical Education, Children's Hospital of Nanjing Medical University, Nanjing 210008 ; 2. Department of Music Therapy, Nanjing Normal University of Special Education, Nanjing 210038 ; 3. School of Sport and Brain Health, Nanjing Sport Institute, Nanjing 210014 ; 4. Department of Rehabilitation Medicine, Affiliated Hospital of Yangzhou University, Yangzhou 225000 ; 5. Department of Rehabilitation Medicine, Children's Hospital of Nanjing Medical University, Nanjing 210008 , China

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    Abstract:

    Objective: To investigate the effect of music therapy on eye movement characteristics of joint attention (JA) in children with autism spectrum disorder (ASD), providing an objective basis for clinical intervention. Methods: A randomized crossover design was employed. Twenty-six ASD children aged 3-10 years were enrolled and randomly assigned to group A or B. They first received either a music therapy intervention or a quiet-sitting control condition, and after a 7-day washout period, crossed over to the alternate condition. Eye-tracking technology was used to record the time to first fixation (TFF) during a joint attention paradigm task (comprising three conditions: Eye Gaze, Eye-Head, and Eye-Head-Gesture). Paired sample t-tests were applied to compare the effects of the music intervention. Results: Following music therapy, the TFF for the total score across all conditions was significantly shorter compared to the quiet-sitting control condition (t=-2.24, P=0.035, Cohen's d=-0.458). Specifically, the TFF in the Eye-Head-Gesture condition was significantly shorter than in the control condition (t=-2.32, P=0.030, Cohen's d=-0.485). Although the TFF in the Eye Gaze and Eye-Head conditions alone showed no statistically significant difference, the mean TFF was shorter than in the control condition. Conclusion: Music therapy can significantly shorten the time to first fixation on joint attention targets in children with ASD, suggesting that it may improve core social deficits by enhancing neural information processing efficiency. Eye movement characteristics may serve as an objective indicator for evaluating the efficacy of music therapy.

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ZHANG Ling, YANG Chang, SHI Yifan, LIU Zhimei, ZHANG Hongmei, SUN Yaojin, DI Siyu, CHEN Aiguo, GAO Funing. The oculomotor mechanism of joint attention in children with autism spectrum disorder based on multimodal neuromodulation music therapy[J].,2026,(7):999-1010.

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History
  • Received:October 10,2025
  • Revised:December 14,2025
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  • Online: July 15,2026
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