[Abstract] Objective: By analyzing the clinical characteristics of septic shock in patients with Pyogenic liver abscess complicated with diabetes, the early risk factors for shock prediction were explored. Methods: The clinical data of 240 diabetic patients with liver abscesses assessed by computerized tomography （CT） in our hospital from January 2017 to April 2021 were collected. According to whether with septic shock occurred or not during hospitalization, they were divided into shock group and non-shock group.The general informations of patients at the first visit, symptoms, basic vital signs, abdominal CT and blood biochemical indicators, etc were analyzed to identify the risk factors of shock. Results: ①Comparing the general data of two groups, there was a significant difference in age (P<0.05). ②There were significant differences in symptoms, respiratory rate, heart rate, and maximum body temperature between the two groups of patients (P<0.05), and the differences in mean arterial pressure and CT manifestations of absess were not statistically significant (P>0.05). ③Compared with the blood test results, the white blood cell count and neutrophil percentage in the shock group were significantly increased compared with the non-shock group, and the platelet count was significantly decreased. ④The prothrombin time, PT international standardized ratio, partial thromboplastin activation time (seconds), and thrombin time were significantly prolonged in the shock group than in the non-shock group (P<0.05). ⑤The binary logistic regression analysis showed that respiratory rate, maximum body temperature and prothrombin time were independent predictors of septic shock. Conclusion: The patient's respiratory rate, maximum body temperature and prothrombin time at the first diagnosis can provide important predictive value for the early identification of shock.