Lipoxin A4 (LXA4) is a natural pro-catabolic molecule produced by endogenous fatty acids that is known as the "brake signal" of inflammatory factors. It has a powerful anti-inflammatory effect, but its metabolism is fast, and LXA4 analogues are relatively more stable and also have certain anti-inflammatory effects. The star cell in the fight against inflammation, the macrophage, is a vital component of our natural immunological barrier and plays a crucial role in inflammation reduction, as does LXA4. LXA4 and its analogs are intricately related to macrophages in the anti-inflammatory process. The interactions between the two in the inflammatory response are examined in order to generate novel ideas for treating a variety of inflammation-related disorders.