OBJECTIVE: To evaluate the early clinical outcomes of no-touch harvesting technique and conventional harvesting technique applied to off-pump coronary artery bypass grafting. METHODS: The clinical data of 120 patients who underwent off-pump coronary artery bypass grafting from July 2020 to July 2022 in the Department of Cardiovascular Surgery of the First Affiliated Hospital of Nanjing Medical University were retrospectively analyzed, of which 50 cases used no-touch harvesting technique (No-touch group) and 70 cases used conventional harvesting technique (CVH group). Observation indexes included operation time, number of venous bridging vessels, average flow rate of venous bridging vessels, mechanical ventilation time, ICU monitoring time, postoperative complications such as poor healing of leg incision and postoperative acute kidney injury, as well as echocardiographic indexes (left ventricular ejection fraction, left ventricular end-diastolic and left ventricular end-systolic diameters) and coronary CT angiography results after 1 year of follow-up. RESULTS: There was no statistically significant difference in operation time, number of venous bridging vessels, average flow rate of venous bridging vessels, mechanical ventilation time and ICU monitoring time between the two groups (P > 0.05). In the No-touch group, there were 5 cases of postoperative IABP support, 2 cases of poor healing of leg incision, and 1 case of postoperative sudden cardiovascular event; in the CVH group, there were 2 cases of postoperative IABP support and 1 case of postoperative acute kidney injury; there were no cases of reoperation and reintubation in the two groups, and the difference in the incidence of postoperative complications was not statistically significant (P > 0.05). There was no statistically significant difference in the postoperative echocardiographic indexes between the two groups at 1 year after surgery (P > 0.05). The rate of venous bridge vessel occlusion in the No-touch group was lower than that in the CVH group at 1 year after surgery, and the difference between the two groups was statistically significant (P < 0.05). CONCLUSION: Compared with conventional harvesting technique, the use of no-touch harvesting technique for saphenous vein harvesting in off-pump coronary artery bypass grafting does not increase the surgical risk, and the patency rate of the bridge vessel is higher at 1 year after surgery.