Research Progress on the Role of Nitric Oxide in Neuropsychiatric Diseases
Affiliation:

Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan); Natural Science Foundation of Jiangsu Province

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    Abstract:

    As a kind of gas signaling molecules, nitric oxide (NO) is involved in the regulation of diverse physiological functions. In the central nervous system, physiological concentration of NO participates in maintaining physiological neuropsychiatric functions, whereas higher concentrations are neurotoxic, which promote several neuropsychiatric diseases through a wide variety of pathological processes. This review discusses the metabolism and functions of NO in the central nervous system. Taking Alzheimer"s disease, Parkinson"s disease, multiple sclerosis, depression and autism as examples, the relationship and pathogenic mechanism of NO with neurodegenerative diseases, neuroinflammatory diseases, mental disorders and neurodevelopmental disorders are described, which provides ideas and impetus for further development of pathogenic mechanism and therapeutic drugs.

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History
  • Received:March 20,2024
  • Revised:May 04,2024
  • Adopted:July 01,2024
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